Ashley Milam, Ph.D.
Assistant Professor
Biology
Education
Research Interests
Milam's research interests are in the area cellular/molecular immunology and autoimmunity, with a focus on the link between affinity for self-antigen, cellular metabolism, and the primary and memory responses of CD4+ T cells. She has studied the role of CD4+ T cells in several disease models, including type 1 diabetes, colitis, EAE/multiple sclerosis, and bacterial infections.
Publications and Media Placements
Milam, A.V., Bartleson, J.M., Donermeyer, D.L., Horvath, S., Durai, V., Raju, S., Yu, H., Redmann, V., Zinselmeyer, B., White, J.M., Murphy, K.M., Allen, P.M. (2018) Tuning T Cell Sensitivity Alters the Behavior of CD4+ T Cells During an Immune Response. J. Immunol. 200(10):3429.
Yokoyama, C.C., Baldridge, M.T.,, Leung, D.W., Zhao, G., Desai, C., Liu, T-C., Diaz-Ochoa, V.E., Huynh, J.P., Kimmey, J.M., Sennott, E.L., Hole, C.R., Idol, R.A., Park, S., Storek, K.M., Wang, C., Hwang, S., Milam, A.V., Chen, E., Kerrinnes, T., Starnbach, M.N., Handley, S.A., Mysorekar, I.U., Allen, P.M., Monack, D.M., Dinauer, M.C., Doering, T.L., Tsolis, R.M., Dworkin, J.E., Stallings, C.L., Amarasinghe, G.K., Micchelli, C.A., Virgin, H.W. (2018) LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens. J. Biol. Chem. 293(16): 6022.
Milam, A.V. and Allen, P.M. (2017) Perspective: The TCR takes some immune responsibility. Immunity 47(5):803.
Redmann, V., Lamb, C.A., Hwang, S., Orchard, R.C., Kim, S., Razi, M., Milam, A., Park, S. Yokoyama, C.C., Kambal, A., Kreamalmeyer, D., Bosch, M.K., Xiao, M., Green, K., Kim, J., Pruett-Miller, S.M., Ornitz, D.M., Allen, P.M., Beatty, W.L., Schmidt, R.E., DiAntonio, A., Tooze, S.A., Virgin, H.W. (2016) Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival. Nat. Sci. Rep. 6: 23326.
Milam, A.V. and Allen, P.M. (2015) Functional Heterogeneity in CD4+ T Cell Responses Against a Bacterial Pathogen. Frontiers Immunol. 6: 621.
Milam, A.A.V., Maher, S.E., Gibson, J.A., Lebastchi, J., Wen, L., Ruddle, N.H., Herold, K.C. and Bothwell, A.L.M. (2014) A Humanized Mouse Model of Autoimmune Insulitis. Diabetes 63(5): 1712-1724.
Sweet, R.A., Ols, M.L., Cullen, J.L., Milam, A.V., Yagita, H. and Shlomchik, M.J. (2011) Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo. Proc. Natl. Acad. Sci. USA. 108(19): 7932-7937.