Carl Gustaf Saluste, Ph.D.
Department of Natural Sciences
Chemistry
Education
M.Sc., University of Lund, Sweden (1996)
Ph.D., University of Southampton, UK (2001)
Practice Areas
- Organic Chemistry (synthesis and methodology)
Publications and Media Placements
Saluste, C.G., Ortega M.A., Pastor, J. et al. 鈥淔ragment-Hopping-Based Discovery of a Novel Chemical Series of Proto-Oncogene PIM-1 Kinase Inhibitors. Plos One, 2012, 7, 1.
Mart铆nez, S., Hern谩ndez, A.I., Rodr铆guez, A., Saluste, C.G. et al. 鈥淚dentification of ETP-46321, a potent and orally bioavailable PI3Ka,d ,-inhibitor鈥. Bioorg. Med. Chem. Lett. 2012, 22, 3460.
Pastor, J., Oyarzabal, J., Saluste, C.G. et al. 鈥淗it-to lead evaluation of 1,2,3-Triazolo [4,5-b] pyridines as PIM-kinase inhibitors鈥. Bioorg. Med. Chem. Lett., 2012, 22, 1591.
Martin, M.W., Newcomb, J., Ghiron, C., Saluste, C.G. et al. 鈥淪tructure-based design of novel 2-amino-6-phenyl-pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR and in vivo anti-inflammatory activity鈥. J. Med. Chem., 2008, 51, 1637.
Saluste, C.G., Crumpler, S., Furber, M., Whitby, R.J. 鈥淧alladium-catalysed synthesis of cyclic amidines and imidates鈥. Tetrahedron Letters, 2004, 45, 6995.
Whitby, R.J., Saluste, C.G., Furber, M. 鈥淪ynthesis of a-iminoimidates by palladium-catalysed double isonitrile insertion鈥. Org. Biomol. Chem., 2004, 2, 1974.
C.G. Saluste, C. Ghiron-Thomas, M. Ermann, P. Amouzeg and E. Power, Patent application with AMGEN Pharmaceuticals, July 2003.
C.G Saluste, R.J Whitby and M. Furber, 鈥淧alladium-catalysed synthesis of imidates, thioimidates and amidines from aryl halides鈥, Tetrahedron Lett., 2001, 42, 6191.
C.G Saluste, R.J Whitby and M. Furber, 鈥淎 Palladium catalysed synthesis of amidines from aryl halides鈥, Angew. Chem. Int. Ed. Engl., 2000, 89, 4156.
C.G. Saluste, U. Berg, N. Bladh, A. Hjelmencrantz and M. Stodeman 鈥淪tructure and Dynamic
Stability of Cyclodextrin Inclusion Complexes with 1,4-Disubstituted Bicyclo-[2.2.2]octanes鈥.
Poster Presentation, 8th Meeting on Stereochemistry August 1998, Tepla, Czeck Republic.
Patents:
Nunes, J., Xiotian, Z., Saluste, C.G. et al. 鈥淪ubstituted Heterocycles and Methods of Use鈥. WO/2005/021551.
Pastor, J., Garc铆a-Collazo, A.M., Saluste, C.G. et al. 鈥淭ricyclic Compounds for Use as Kinase Inhibitors鈥. WO/2011/080510.
Pevarello, P., Garc铆a-Collazo, A.M., Saluste, C.G. et al. 鈥淚midazopyridazines for Use as Protein Kinase Inhibitors鈥. US/2011/0046127.
Pastor, J., Oyarzabal, J., Saluste, C.G. et al. 鈥淭riazolo [4,5-b]pyridine derivatives鈥. WO/2011/101644.
Stay as guest researcher:
05/2017-07/2017: CNIO, Madrid, Spain: Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Crosslinkers to be tested for incorporation to Kinase inhibitors.
01/2015-05/2015: Universidad Complutense, Madrid, Spain: Preparation of synthetic metabolites for pathogenic bacteria, part of the human bacteriotal.