Jinsong Zhang, Ph.D. SLU

Jinsong Zhang, Ph.D.

Associate Professor
Pharmacological and Physiological Science

Education

Postdoctoral Fellow, Rockefeller University, 1999-2005
Advisor: Dr. Robert G. Roeder
- Special Fellow, Leukemia and Lymphoma Society, 2003-2006
- Fellow, Leukemia and Lymphoma Society, 2000-2003
PhD in Biochemistry, University of Pennsylvania, 1995-1999
Advisor: Dr. Mitchell A. Lazar
MS in Biochemistry, Shanghai Institute of Biochemistry, Academia Sinica, 1988-1991
Advisor: Prof. Wang-Yi Liu
BS in Biochemistry, Nanjing University, 1984-1988

Research

My research focuses on transcription (the process of transcribing the genetic information from DNA to RNA). Transcription is regulated in different rate-limiting steps. My research focuses on the early steps in the recruitment and function of transcription factors and coregulators (coactivators and corepressors). For coregulators, we study scaffold proteins as well as enzymes such as histone deacetylases (HDACs) and histone acetyltransferases (HATs).

Our research uses interdisciplinary tools encompassing both reductive and systems approaches, such as assays for measuring protein-protein and protein-DNA interactions, assays for measuring transcription rates of model and natural genes, structure-functional studies by mutagenesis and molecular dynamics simulations, genome-wide analysis of chromatin occupancy (ChIP-Seq) and gene transcription at the global (RNA-Seq) and single-cell levels (scRNA-Seq), mouse knockouts, modeling disease progression using patient-derived xenografts (PDXs), and analysis of patient samples, including those available in the TCGA and TARGET datasets.

Research Interests

Novel druggable targets in cancer with a focus on acute myeloid leukemia
Mechanism and structural basis of transcription, epigenetics, and cell signaling
Drug resistance in cancer with a focus on acute myeloid leukemia
Bioinformatics, computational biology, and high-throughput sequencing

Publications

Featured Research Articles

2020 Steinauer N, Guo C, Zhang J, The transcriptional corepressor CBFA2T3 inhibits all-trans-retinoic acid-induced myeloid gene expression and differentiation in acute myeloidleukemia, J Biol Chem 295:8887-8900,

2019 Steinauer N, Guo C, Huang C, Wong M, Tu Y, Freter C E, Zhang J, Myeloid translocation gene CBFA2T3 directs a relapse gene program and determines patient-specific outcomes in AML, Blood Adv 3:1379-1393,

2015 Guo C, Li Y, Gow C H, Wong M, Zha J, Yan C, Liu H, Wang Y, Burris T P, Zhang J, The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor gamma requires G protein pathway suppressor 2, Journal of Biological Chemistry 290:3666-3679,

2011 Hu Q, Guo C, Li Y, Aronow B J, Zhang J, LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration, Mol Cell Biol 31:3223-40,

2009 Guo C, Hu Q, Yan C, Zhang J, Multivalent binding of the ETO corepressor to E proteins facilitates dual repression controls targeting chromatin and the basal transcription machinery, Mol Cell Biol 29:2644-57,

2004 Zhang J, Kalkum M, Yamamura S, Chait B T, Roeder R G, E protein silencing by the leukemogenic AML1-ETO fusion protein, Science 305:1286-9

2002 Zhang J, Kalkum M, Chait B T, Roeder R G, The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2, Molecular Cell 9:611-623

1998 Gelmetti V, Zhang J (co-first author), Fanelli M, Minucci S, Pelicci P G, Lazar M A, Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO, Mol Cell Biol 18:7185-91

1992 Zhang J S, Liu W Y, The mechanism of action of trichosanthin on eukaryotic ribosomes鈥揜NA N-glycosidase activity of the cytotoxin, Nucleic Acids Res 20:1271-5

Complete List of Research Articles

2022 Braden K, Campolo M, Li Y, Chen Z, Doyle T M, Giancotti L A, Esposito E, Zhang J, Cuzzocrea S, Arnatt C K, Salvemini D, Activation of GPR183 by 7alpha,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through Mitogen-Activated Protein Kinase and Nuclear Factor-kappaB, The Journal of pharmacology and experimental therapeutics 383:172 鈥� 181-172 鈥� 181

2022 Griffett K, Hayes M, Bedia-Diaz G, Appourchaux K, Sanders R, Boeckman M P, Koelblen T, Zhang J, Schulman I G, Elgendy B, Burris T P, Antihyperlipidemic Activity of Gut-Restricted LXR Inverse Agonists, ACS Chem Biol 17:1143-1154

2022 Sur Subhayan, Steele Robert, Ko Ben C B, Zhang J, Ray Ratna B, Long noncoding RNA ELDR promotes cell cycle progression in normal oral keratinocytes through induction of a CTCFFOXM1-AURKA signaling axis, Journal of Biological Chemistry 298:101895

2021 Banerjee S, Ghoshal S, Girardet C, DeMars K M, Yang C, Niehoff M L, Nguyen A D, Jayanth P, Hoelscher B A, Xu F, Banks W A, Hansen K M, Zhang J, Candelario-Jalil E, Farr S A, Butler A A, Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice, NPJ Aging Mech Dis 7:23

2021 Ghoshal S, Banerjee S, Zhang J, Niehoff M L, Farr S A, Butler A A, Adropin transgenesis improves recognition memory in diet-induced obese LDLR-deficient C57BL/6J mice, Peptides 146:170678,

2021 Khatun M, Zhang J, Ray R, Ray R B, Hepatitis C virus evades interferon signaling by suppressing long noncoding RNA linc-pint involving C/EBP-b, Journal of Virology 95:e00952-21

2021 Li J, Guo C, Rood C, Zhang J, A C terminus鈥揹ependent conformational change is required for HDAC3 activation by nuclear receptor corepressors, Journal of Biological Chemistry 279:101192

2021 Mukherjee S, Chakraborty M, Ulmasov B, McCommis K, Zhang J, Carpenter D, Msengi E N, Haubner J, Guo C, Pike D P, Ghoshal S, Ford D A, Neuschwander-Tetri B A, Chakraborty A, Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis, Mol Metab 54:101364

2021 Steinauer N, Zhang K, Guo C, Zhang J, Computational Modeling of Gene-Specific Transcriptional Repression, Activation and Chromatin Interactions in Leukemogenesis by LASSO-Regularized Logistic Regression, IEEE/ACM Trans Comput Biol Bioinform 18:2109-2122

2020 Banerjee S, Ghoshal S, Stevens J R, McCommis K S, Gao S, Castro-Sepulveda M, Mizgier M L, Girardet C, Ganesh Kumar K, Galgani J E, Niehoff M L, Farr S A, Zhang J, Butler A A, Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction, Journal of Biological Chemistry 295:13753-13768

2020 Griffin P, Sheehan P W, Dimitry J M, Guo C, Kanan M F, Lee J, Zhang J, Musiek E S,

Rev-erb alpha mediates complement expression and diurnal regulation of microglial synaptic phagocytosis, eLife 9:1-17

2020 Guo C, Li J, Steinauer N, Wong M, Wu B, Dickson A, Kalkum M, Zhang J, Histone deacetylase 3 preferentially binds and collaborates with the transcription factor RUNX1 to repress AML1-ETO-dependent transcription in t(8;21) AML, J Biol Chem 295:4212-4223

2020 Lananna B V, McKee C A, King M W, Del-Aguila J L, Dimitry J M, Farias F H G, Nadarajah C J, Xiong D D, Guo C, Cammack A J, Elias J A, Zhang J, Cruchaga C, Musiek E S, Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer鈥檚 disease pathogenesis, Science Translational Medicine 12:eaax3519

2020 Yosten G L, Harada C M, Haddock C, Giancotti L A, Kolar G R, Patel R, Guo C, Chen Z, Zhang J, Doyle T M, Dickenson A H, Samson W K, Salvemini D, GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents, J Clin Invest 130:2587-2592

2019 Butler A A, Zhang J, Price C A, Stevens J R, Graham J L, Stanhope K L, King S, Krauss R M, Bremer A A, Havel P J, Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates, J Biol Chem 294:9706-9719

2019 Carpenter K J, Valfort A C, Steinauer N, Chatterjee A, Abuirqeba S, Majidi S, Sengupta M, Di Paolo R J, Shornick L P, Zhang J, Flaveny C A, LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer, Sci Rep 9:19530

2019 Griffin P, Dimitry J M, Sheehan P W, Lananna B V, Guo C, Robinette M L, Hayes M E, Cede帽o M R, Nadarajah C J, Ezerskiy L A, Colonna M, Zhang J, Bauer A Q, Burris T P, Musiek E S, Circadian clock protein Rev-erb alpha regulates neuroinflammation, Proceedings of the National Academy of Sciences of the United States of America 116:5102-5107

2019 Roby D A, Ruiz F, Kermath B A, Voorhees J R, Niehoff M, Zhang J, Morley J E, Musiek E S, Farr S A, Burris T P, Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-beta burden in a mouse model of Alzheimer鈥檚 disease, PLoS One 14:e0215004

2018 Cui N, Zhang J, Huang H, Lu L, Epigenetic regulator ARID1A and stem cell transcription factor SOX9 in the maintenance of pancreatic ductal cell differentiation state and development of intraductal papillary mucinous neoplasia (IPMN) and pancreatic ductal adenocarcinoma (PDAC), Translational Cancer Research 7:S748-S751

2018 Ghoshal S, Stevens J R, Billon C, Girardet C, Sitaula S, Leon A S, Rao D C, Skinner J S, Rankinen T, Bouchard C, Nu帽ez M V, Stanhope K L, Howatt D A, Daugherty A, Zhang J, Schuelke M, Weiss E P, Coffey A R, Bennett B J, Sethupathy P, Burris T P, Havel P J, Butler A A, Adropin: An endocrine link between the biological clock and cholesterol homeostasis, Molecular Metabolism 8:51-64

2017 Lin S, Ptasinska A, Chen X, Shrestha M, Assi S A, Chin P S, Imperato M R, Aronow B J, Zhang J, Weirauch M T, Bonifer C, Mulloy J C, A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program, Blood 130:1213-1222

2017 Sitaula S, Zhang J, Ruiz F, Burris T P, Rev-erb regulation of cholesterologenesis, Biochem Pharmacol 131:68-77

2017 Welch R D, Guo C, Sengupta M, Carpenter K J, Stephens N A, Arnett S A, Meyers M J, Sparks L M, Smith S R, Zhang J, Burris T P, Flaveny C A, Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome, Mol Metab 6:703-714

2017 Zhang L, Liu Y, Wang M, Wu Z, Li N, Zhang J, Yang C, EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients, J Mol Cell Biol 9:477-488

2014 Gow C H, Guo C, Wang D, Hu Q, Zhang J, Differential involvement of E2A-corepressor interactions in distinct leukemogenic pathways, Nucleic Acids Res 42:137-52

2013 Benavides M, Chow-Tsang L F, Zhang J, Zhong H, The novel interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression, Biochimica et Biophysica Acta - Molecular Cell Research 1833:21-32,

2013 Chen W Y, Zhang J, Geng H, Du Z, Nakadai T, Roeder R G, A TAF4 coactivator function for E proteins that involves enhanced TFIID binding, Genes and Development 27:1596-1609,

2013 Feng Y, Singleton D, Guo C, Gardner A, Pakala S, Kumar R, Jensen E, Zhang J, Khan S, DNA homologous recombination factor SFR1 physically and functionally interacts with estrogen receptor alpha, PLoS One 8:e68075,

2012 Guo C, Gow C H, Li Y, Gardner A, Khan S, Zhang J, Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes, J Biol Chem 287:12111-20,

2011 Wang L, Gural A, Sun X J, Zhao X, Perna F, Huang G, Hatlen M A, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole P A, Zhang J, Melnick A, Roeder R G, Nimer S D, The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation, Science 333:765-769,

2010 Olshavsky N A, Comstock C E S, Schiewer M J, Augello M A, Hyslop T, Sette C, Zhang J, Parysek L M, Knudsen K E, Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene, Cancer Research 70:3975-3984,

2009 Guo C, Hu Q, Yan C, Zhang J, Multivalent binding of the ETO corepressor to E proteins facilitates dual repression controls targeting chromatin and the basal transcription machinery, Mol Cell Biol 29:2644-57

2008 Lee K, Liu Y, Mo J Q, Zhang J, Dong Z, Lu S, Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer, BMC Cancer 8:158,

2006 Plevin M J, Zhang J, Guo C, Roeder R G, Ikura M, The acute myeloid leukemia fusion protein AML1-ETO targets E proteins via a paired amphipathic helix-like TBP-associated factor homology domain, Proc Natl Acad Sci U S A 103:10242-10247,

2004 Zhang J, Kalkum M, Yamamura S, Chait B T, Roeder R G, E protein silencing by the leukemogenic AML1-ETO fusion protein, Science 305:1286-9

2002 Hug B A, Lee S Y, Kinsler E L, Zhang J, Lazar M A, Cooperative function of Aml1-ETO corepressor recruitment domains in the expansion of primary bone marrow cells, Cancer Res 62:2906-12

2002 Zhang J, Kalkum M, Chait B T, Roeder R G, The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2, Molecular Cell 9:611-623

2001 Zhang J, Hug B A, Huang E Y, Chen C W, Gelmetti V, Maccarana M, Minucci S, Pelicci P G, Lazar M A, Oligomerization of ETO is obligatory for corepressor interaction, Molecular and Cellular Biology 21:156-163

2000 Huang E Y, Zhang J, Miska E A, Guenther M G, Kouzarides T, Lazar M A, Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway, Genes Dev 14:45-54

1999 Zhang J, Hu X, Lazar M A, A novel role for helix 12 of retinoid X receptor in regulating repression, Mol Cell Biol 19:6448-57

1998 Zhang J, Guenther M G, Carthew R W, Lazar M A, Proteasomal regulation of nuclear receptor corepressor-mediated repression, Genes Dev 12:1775-80

1997 Zamir I, Zhang J, Lazar M A, Stoichiometric and steric principles governing repression by nuclear hormone receptors, Genes Dev 11:835-46

1997 Zhang J, Zamir I, Lazar M A, Differential recognition of liganded and unliganded thyroid hormone receptor by retinoid X receptor regulates transcriptional repression, Mol Cell Biol 17:6887-97

1996 Reginato M J, Zhang J, Lazar M A, DNA-independent and DNA-dependent mechanisms regulate the differential heterodimerization of the isoforms of the thyroid hormone receptor with retinoid X receptor, J Biol Chem 271:28199-205,

1994 Zhang J, Yeh M, Cloning, sequencing and analyzing of the heavy chain V region genes of human polyreactive antibodies, Cell Research 4:31-46

1993 Zhang J, Yeh M, Characterizing genes encoding the variable regions of heavy chains of human polyreactive antibodies, Progress in Biochemistry and Biophysics 20:40-41

1992 Zhang J, Liu W Y, Identification of the catalytic site of Trichosanthin on eukaryotic ribosomal 28S RNA, Progress in Biochemistry and Biophysics 19:131-131

1992 Zhang J S, Liu W Y, The mechanism of action of trichosanthin on eukaryotic ribosomes鈥揜NA N-glycosidase activity of the cytotoxin, Nucleic Acids Res 20:1271-5,

Editorial and Review Articles

2017 Zhang J, Gow C H, Khan S, Liu Y, Yang C, Transcriptional and Genomic Control of Stem Cells in Development and Cancer, Stem Cells Int 2017:2513598,

2017 Steinauer N, Guo C, Zhang J, Emerging Roles of MTG16 in Cell-Fate Control of Hematopoietic Stem Cells and Cancer, Stem Cells Int 2017:6301385

2016 Li J, Guo C, Steinauer N, Zhang J, New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins, Frontiers in Biology 11:285-304

2014 Wong M M, Guo C, Zhang J, Nuclear receptor corepressor complexes in cancer: mechanism, function and regulation, Am J Clin Exp Urol 2:169-87

2000 Zhang J, Lazar M A, The mechanism of action of thyroid hormones, Annu Rev Physiol 62:439-66,

1994 Zhang J, Liu W Y, Progress in topography of ribosomal RNA and RNA N-glycosidase research (I), Progress in Biochemistry and Biophysics 21:23-7

1994 Zhang J, Liu W Y, Progress in topography of ribosomal RNA and RNA N-glycosidase research (II), Progress in Biochemistry and Biophysics 21:113-117,

HIGH-THROUGHPUT DEEP SEQUENCING AND PROTEOMICS DATASETS

GSE143895, GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents

PXD017230, human HDAC3 and interesting proteins

GSE131939, Paired ChIP-Seq studies of Kasumi-1 t(8;21) AML cells

GSE126953, ChIP-Seq of CBFA2T3 (ETO2) in CD34+ HSPC and AML cells

GSE72427, Binding site-dependent effects of AML1-ETO leukemia fusion protein on RNA Pol II pausing and enhancer activation

Conference Abstracts

Oral Presentation

2021 Steinauer N, Guo C and Zhang J. Deciphering gene regulatory networks via logistic regression of cistromic and transcriptomic features in disease models. AlCoB 2020/2021, 7th International Conference on Algorithms for Computational Biology, Missoula, Montana, USA (Selected for oral presentation)

2016 Steinauer N, Wong M, Guo C, Freter CE, and Zhang J. A novel CD34/ETO2/IFNGR gene regulatory axis Is implicated in poor-prognosis cases of t(8;21) AML. September 16-17, 2016. 2016 ASH Meeting on Hematologic Malignancies. Chicago. IL Oral Presentation.

2012 Duan X, Guo C, Gardner A, Khan S and Zhang J. A novel histone deacetylase complex plays both coactivator and corepressor roles in AIB1 transcription, 5th Biennial Great Lakes Nuclear Receptor Conference. Date: October 12-13, 2012, Northwestern University, Chicago, IL. Oral Presentation.

2009 Guo C, Vasiliauskas J and Zhang J. GPS2 facilitates functional nuclear receptor corepressor-PPARgamma interaction in vivo. Cincinnati Cancer Symposium: 2009 Jensen Symposium on Nuclear Receptors. Date: Oct 14-15, 2009. Cincinnati, OH. Oral presentation.

2007 Yan C, Hu Q, Guo C, Kalkum M and Zhang J. Novel histone deacetylase complexes that contain nuclear receptor coactivators involved in estrogen receptor function. Midwest Regional Molecular Endocrinology Conference. Date: May 18, 2007. Indianapolis, IN. Oral presentation.

2007 Zhang J and Guo C. Novel mechanisms of transcriptional corepressor functions in normal and disease-associated pathways. Midwest Regional Molecular Endocrinology Conference. Date: May 18, 2007. Indianapolis, IN. Oral presentation.

Poster presentation

2022 Morgan J, Guo C, Huang C, Steinauer N., Scannell A, Goyal S and Zhang J. TBLR1 Maintains Retinoic Acid Resistance in Non-APL Acute Myeloid Leukemia by Inhibiting RARa Recruitment2022 Cancer Research Symposium, December 9, 2022, Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine at St. Louis, St. Louis, MO.

2022 Schafer R, Giancotti L, Chen Z, Doyle T, Harada C, Zhang J, Salvemini D. A Role of NOD2 in CARTp-mediated Mechano-hypersensitivity. EXPERIMENTAL BIOLOGY 2022. Philadelphia, Pennsylvania, USA. April 2-5, 2022

2022 Braden K, Campolo M, Chen Z, Giancotti, LA, Li Y, Doyle TM, Esposito E, Zhang J, Salvemini D. Investigating the Molecular Mechanisms Driving 7alpha,25-dihydroxycholesterol-GPR183-Induced Hypersensitivity. EXPERIMENTAL BIOLOGY 2022. Philadelphia, Pennsylvania, USA. April 2-5, 2022

2018 Steinauer N, Guo C, Wong M, Freter CE, and Zhang J. Differential regulation of ETO2 gene expression determines patient-specific outcome in acute myeloid leukemia. Advancing Precision Medicine through Translational Genomics. 1st Annual ICTS Symposium. January 16, 2018. Washington University in St. Louis. St Louis, MO.

2017 Steinauer N, Guo C, Wong M, Freter CE, and Zhang J. ETO2 Regulates Cell-Fate Genes and Controls Relapse in Acute Myeloid Leukemia. 59th ASH Annual Meeting, Atlanta, GA, USA, 2017. December 9-12, 2017. Poster Presentation.

2016 Steinauer N, Guo C, Wong M, Freter CE, and Zhang J. A novel CD34/ETO2/IFNGR gene regulatory axis is implicated in poor prognosis cases of t(8;21) AML. ASH Annual Meeting, San Diego, CA, USA, 2016. December 3-6, 2016. Poster Presentation.

2015 Guo C, Madeline M. Wong M, Chien-Hung Gow C-H, Zha J and Zhang J. RNA polymerase II is a direct and functional target of the AML1-ETO leukemia fusion protein. EVOLUTION AND CORE PROCESSES IN GENE REGULATION. June 25-28, 2015, Washington University, St. Louis, MO. Poster Presentation.

2015 Guo C, Wong M, Steinauer N, Chien-Hung Gow C-H and Zhang J. A leukemogenic strategy to enforce promoter-proximal pausing and enhancer elongation of RNA polymerase II in a gene-specific manner. MECHANISMS OF EUKARYOTIC TRANSCRIPTION. August 25鈥揂ugust 29, 2015. Cold Spring Harbor Laboratories, Cold Spring Harbor, NY. Poster Presentation.

2015 Steinauer N, Wong M, Guo C, Freter CE, and Zhang J. The stem cell marker gene CD34 is transcriptionally activated by t(8;21) leukemia fusion proteins. The 2015 Midwest Regional Meeting of the American Physician Scientists Association (APSA). October 24, 2015. St. Louis, MO. Poster Presentation.

2014 Pouncil G, Guo C, Wong, MM and Zhang J. The transcriptional activity of AML1-ETO requires its interactions with E-proteins. 2014 Undergraduate Research/Graduate School (URGS) Retreat. Date: September 26-27, 2014, University of Tennessee, Knoxville, TN. Poster Presentation.

2012 Gow C-H, Guo C and Zhang J. Inter-domain crosstalk modulates E2A sensitivity to ETO-mediated repression. NIDDK workshop on Regulatory Determinants of Hematopoietic Stem Cell Differentiation and Terminal Development: New Insights. Date: February 20, 2012. Washington DC. Poster Presentation.

2012 Gow C-H, Guo C and Zhang J. Inter-domain crosstalk modulates E2A sensitivity to ETO-mediated repression. The 10th Midwest Blood Club Symposium. Date: March 15-16, 2012, Indianapolis, IN. Poster Presentation.

2012 Gow C-H, Guo C, Duan X and Zhang J. E-proteins are essential cooperative factors for transcriptional repression mediated by the AML1-ETO leukemia fusion protein. Transcriptional regulation: Chromatin and RNA Polymerase II. Date: October 4-8, 2012, Snowbird, UT. Poster Presentation.

2007 Guo C, Hu Q, Yan C and Zhang J. ETO domain crosstalk specifies two pathways in the repression of E protein-mediated transcription. Cold Spring Harbor Laboratory Meeting on Mechanisms of Eukaryotic Transcription. Date: Aug 29-Sep 2, 2007. Cold Spring Harbor, NY. Poster presentation.

2007 Guo C, Zhang J. Novel mechanisms of post-transcriptional regulation of HDAC3. Midwest Regional Molecular Endocrinology Conference. Date: May 18, 2007. Indianapolis, IN. Oral presentation.

2006 Gural A, Jankovic V, Zhang J, Roeder RG, Nimer SD. The deletion of NHR1 region of the AML1-ETO protein significantly decreases its ability to promote proliferation and self-renewal of early hematopoietic cells in culture. 48th Annual Meeting of the American-Society-of-Hematology. Date: Dec 09-12, 2006. Orlando, FL. Poster Presentation.

2004 Zhang J, Kalkum M, Yamamura S, Chait BT and Roeder RG. E protein silencing by the leukemogenic AML1-ETO fusion protein. The Leukemia and Lymphoma Society Stohlman Scholar Symposium. Date: Nov 2004. St. Louis, MO. Poster presentation.

2002 Zhang J, Kalkum M, Chait BT and Roeder RG. The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through a novel integral subunit GPS2. Keystone Symposia on Nuclear Receptor Superfamily. Date: Apr 13-19, 2002. Poster presentation.

1998 Zhang J, Gelmetti V, Fanelli M, Minucci S, Pelicci PG and Lazar MA. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. NIH Workshop: Co-Activators and Co-Repressors in Gene Expression. Date: Dec 15-16, 1998. Bethesda, MD. Poster presentation.

Professional Organizations and Associations

American Society of Hematology
American Association for the Advancement of Science
American Society for Biochemistry and Molecular Biology

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